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II. Synergism the combined effect of drugs is more than the
algebraic sum of their individual actions i.e. A = 1, B = 1, A + B >
2.

III. Potentiation  one drug has no action on a system but increases the

action of another drug on the same system i.e. A = 0, B = 1, A + B > 1.

III. Antagonism  several types: (we discuss later after
pharmacokinetic interactions)

B. Pharmacokinetic Interactions

 Absorption Salts of Mg, Ca & Al limit absorption of

tetracycline.
 Distribution displacement from plasma protein binding sites
(see interaction between aspirin & warfarin).
Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman