Page 41 - Pharmacology Mnemonics and Short Notes

33

1-Hemolysis of RBCs in patients with G6PD deficiency due to
administration of certain drugs as aspirin.

Predictable

1. Carcinogenicity drug induced cancer.

2. Mutagenicity drug induced gene mutations in parents or in their

offspring.

3. Teratogenicity drug induced foetal defects in utero. Drugs are safely

avoided as much as we can especially during the first trimester.
4. Cummulation (Toxicity) drug induced poisoning either due single

large dose or several small doses.

5. Tolerance decreased drug response the usual dose on repeated
administration of the drug. Tolerance may be congenital (inherited) OR

Acquired.

1. Congenital:

a) Racial: Negroes are resistant to mydriatic effect of ephedrine.
b) Species: rabbits are resistant to atropine due to presence of

atropinase enzyme.
Contents c) Individual variation.

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman