Page 36 - Pharmacology Mnemonics and Short Notes

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A graph of increase response to increasing drug concentration

Graded dose response

Graded Dose response
Graph between Increase of response Increase of dose of

drug
Data derived from this Graph

 Efficacy (E max)
 Potency ( EC 50 or ED 50)
Smaller the EC 50 greater the potency of drug
Quantal dose response

A graph of fraction of population that shows a specific response at
progressively increasing dose
Quantal dose response
Quantal Dose response

Graph between Fraction of population Increase of dose of
showing that drug

response
Data derived from this Graph

 Median effective dose (ED 50)
 Median toxic dose (TD 50)
 Median lethal dose (LD 50)  in animals

Efficacy greatest effect
is the greatest effect (E max) an agonist can produce if dose is taken to

highest tolerated level
Determined by

 Nature of the drug

 Nature of the receptor

 Nature of the effector system associated with it

 can be determined by graded response curve not by Quantal
Contents response curve

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman