Page 32 - Pharmacology Mnemonics and Short Notes

24

It is the time needed to reduce drug plasma
concentration by 50%. The longer the half-life
of the drug the lesser the frequency of drug

administration.

Half-life =
0.693 x V d
Clearance

Half-life  determines the rate at which blood
concentration rises during constant infusion

and falls after stopped
Dosage regimens
A plan of drug administration over a period of time

 Achieve therapeutic level of drug without achieving the minimum
toxic level of the drug.
Maintenance Dose

Dose required for regular administration to maintain plasma level

CL x Desired plasma concentration
Dosing rate =
Bioavailability

Bioavailability for IV route is 1 so we can say that
Dosing rate = CL x Desired plasma level

Loading dose (Love  mean Loading dose have V d)
Dose required to achieve specific plasma level with single administration
 Therapeutic concentration must be achieved rapidly at the onset of

therapy

Dosing rate = V d x Desired plasma concentration
Bioavailability

Bioavailability for IV route is 1 so we can say that

Dosing rate = V d x Desired plasma level
 Clearance is not needed here because when clearance will start we
Contents will give patient maintenance dose

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman