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Klingeborn et al.                                                                  Page 40















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                               Figure 1. Publications with the keyword “exosomes” in the NCBI PubMed database as of
                               December 2016
                               Note the exponential growth in the number of published articles, in particular in the last
                               decade. (Inset) Publications with the indicated search terms in the NCBI PubMed database
                               show a significant increase of exosome publications in the cancer (blue), immune (white),
                               and more recently cardiovascular (gray) research fields; while the eye research field (green)
                               is trailing far behind with only 8 articles in each of the last two years.


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                                  Prog Retin Eye Res. Author manuscript; available in PMC 2018 July 01.
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