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Klingeborn et al. Page 42
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Figure 3. The corticosteroid, dexamethasone (Dex) treatment of human trabecular meshwork
explants increases fibronectin secretion but decreases exosome affinity for fibronectin (Fn)
surface
Western blot analysis of exosome-depleted conditioned media and exosomes isolated from
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conditioned media atop cultured human trabecular meshwork explants in the presence or
absence of 100 nM dexamethasone for 72 hrs. Fibronectin content in exosome preparations
was normalized to particle number using nanoparticle tracking analysis and quantified via
densitometry (n=6) (Dismuke et al., 2016). Permission pending.
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Author Manuscript
Prog Retin Eye Res. Author manuscript; available in PMC 2018 July 01.
