Page 41 - Chow Life - Summer 2016 Issue

flora, and outside influences such
as antibiotics can have a long term
effect on dysbiosis as in the case
of G.I. disorders like IBD. The skin
microbiome has its own ecosystem
of bacteria and fungi which help
prevent infection by pathogens;
microbiome varies between
individuals and skin sites. In his
study Dr. Suchodolski found dogs
with AD had less divergent and
fewer numbers of fungal species
than healthy dogs. New applications
are needed for developing strategies
to counter the long-term effects of
dysbiosis resulting from antibiotic
treatments used for skin disease and
IBD. Dr. Charles Bradley touched
on some of the same findings in
his presentation on The Cutaneous
Microbiome and Resistome of
Healthy and Atopic Dogs, including
the findings that cutaneous
microbiome in dogs affected
with an AD showed decreased
microbial diversity with increased
numbers of Staphylococcus and
Corynebacterium during atopic
flares. Findings show a genetic
component is evident by breed
disposition and linked to high IGE
production which is a dominant
trait mutation along particular
genome sites.
The topic of Zoonotic disease
was addressed in presentations
done on Hunting Brucellosis, by
Dr. Matthew Krecic and Evidence-
Based Recommendations for
Reduction of Infectious Disease in
Canine Group Settings, by Dr. Jason
Stull. Brucellosis caused by Brucella personalized
Canis which is intracellular, is many cancer treatments. His research
times asymptomatic especially in
the stud dog, and one for which
there is no effective treatment.
The disease is worldwide with an
increasing prevalence in the US
and is transmitted through urine,
aborted fetuses, vaginal secretion,
inhaled, or ingested and is likely
significantly under reported.
Whether it's a MRSA or Zoonotic
infection, disease can post a risk to area of stem cell treatment for joint significant findings between altered
both dogs and the humans they're
in contact with and can quickly
become a challenge for both, and
the presentations considered ways
to combat the spread of diseases, as study. Dr. Jennifer Barrett did a pre-
antibiotic resistant bacteria become sentation on stem cell therapy for
an increasing worldwide challenge. Supraspinatus Tendonopathy. She
pointed out all species are connect-
Another disease that is a ed as the research crosses species
challenge for both dogs and and regenerative treatment is hope
humans is cancer and the study for a cure. Regenerative therapy's
presentations emphasize the goal is for the healing of injured
evidence that understanding disease tissue back to original quality with
in multiple species will help us normal function and no scar forma-
find treatments more quickly than tion, using stem cell treatments and
looking at one species at a time, platelet rich plasma (PRP). Op-
again bringing in the theme of "one tions for stem cell sources include
species". Several presentations we're zygotes which can be turned into
done in studies looking into novel embryonic stem cells, and adult
treatments of this disease such stem cells. Embryonic stem cells
as use of conditionally replicative can be made into any tissue but
adenovirus, the immune systems replicate rapidly so they're hard to
response to the virus, and the control and can become cancerous.
potential for long-term survival Adult stem cells are used the most
in dogs with osteosarcoma when in this research because they are
treated with the virus, presented multipotent and easier to control.
by Dr. Bruce Smith. Dr. Jeffrey As aging occurs, the stress placed
Bryan presented a research on the tendons causes breakdown
project studying immunotherapy of the collagen matrix and a loss of
agents targeted to the low elasticity. The goal of PRP and stem
oxygen environment of cancer, cell therapy is to restore structure
an herbal derivative that targets to the tendon. Platelet rich plasma
iron in tumors, and nanoparticle encourages stem cell growth and
chemotherapy. These treatments are provides a place for the stem cells to
destined for use in both dogs and stick to. Her clinical trial was on the
humans, designed and developed supraspinatus shoulder tendon of
as an approach that is less toxic and
more effective
than our
current cancer An area of treatment that is
treatments. seeing encouraging results is in
A third the area of stem cell treatment
presentation
was given for joint therapy and repair.
by Dr. Doug
Thamm on
57 dogs. It's the injury most com-
interest include targeted therapies mon to the canine shoulder across
for animal and human cancer and all breeds (especially in agility) and
ways to integrate these therapies in people so cross species applies.
with current treatments. The results This clinical study was isolated to
of these studies show there is still shoulder injuries only but they're
much research to be done in the actively investigating the use of
areas of cancer treatments. these treatments for other cases of
osteoarthritis. Stem cells and PRP
An area of treatment that is see- showed significant improvement
ing encouraging results is in the at only 4-6 weeks. There were no
therapy and repair. The stem cell or unaltered cases, ages or breeds.
presentations included situations Due to the acceleration of cell
in which stem cell therapy could be growth, they don't allow dogs
used, sources for stem cells, and the with tumors to be included in
resulting tissue repair seen in the
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