Page 42 - Chow Life - Summer 2016 Issue

the study, as it's unknown if it could lesion bed in the affected joint. The characteristics of the pelvic limbs
cause problems in dogs with tumors graft integrates and restore function that are thought to be contributing
and metastasis. CHF is sponsor- but creates a problem with donor factors; by looking at standing
ing new clinical study on bilateral site morbidity. Tissue engineering angles, range of motion, muscle
supraspinatus injury and they need creates new hope and a promising mass, and development of the
recruited cases. Dr. Brian Saun- treatment for dogs suffering from hip-stifle joint relationship. An
ders also gave a presentation on OCD, OA or other joint problems, earlier study, by Dr. Griffon's team,
Regenerative Medicine Techniques using stem cells and Regenerated yielded an equation based on
to Treat Cartilage Disorders. He Osteochondral Plugs (ROPS) for radiographic features of the tibia
hopes to advance the use of stem healing and cartilage repair. These and femur to calculate a predictive
cell therapy in canine orthopedics cylinder plugs are composed of tri- score and a large scale study has
for the mutual benefit of veterinary layered hydrogel scaffolds, a mate- just been completed to validate the
and human orthopedic patients and rial similar to material used to make ability of this equation to predict
his session covered the advances soft contacts, seeded with adult CCLD. It is the leading cause of
in regenerative medicine applied mesenchymal stem cells (MSCs) lameness and DJD in stifles and
to dogs with osteochondrosis and that closely mimic specific zones 40% of those affected have the
osteoarthrits. The typical joint in the joint and adjacent bone. The disease in both legs. In her study
is made up of low friction, wear layers are bioactive, directing the they measured the tibia plateau
resistant tissue with cartilage that encapsulated MSC's to differentiate angle (TPA) which is the place on
has no nerves or blood vessels so into specific tissues to restore nor- the tibia which takes the most force
its repair ability is limited. In dogs mal joint anatomy and function and from the femur during movement.
with Osteochondral Defects (OCD) eliminates the problem of donor They found the greater the Tibia
there is an abnormality in the pro- site morbidity caused by osteochon- thrust the greater the chance of
dral transfer. developing CL rupture due to
Canine MSCs abnormal forces. They also looked
Treatment options for diseases are hold much at how muscles work in gait analysis
important but in some cases, being promise for and found muscle mass imbalance
able to predict disease and the ortho disease predisposes toward the disease.
and they're The femoral anteversion angle
removal affected animals from the now looking (FAA) is the equation of the angle
breeding pool is the best option at MSCs for of the femoral condyle, where the
bone regen- femur contacts the tibia, in relation
eration. Us- to the femoral neck. This angle is
ing PEG scaf- found by measuring the rotation, an
folds is close actual twist, in the femur as seen on
cess by which growth plate cartilage to be a viable treatment option for radiographs, which places abnormal
transitions from cartilage to bone OCD treatment and joint rebuild- stress on the stifle joint and cruciate
resulting in excessively thickened ing. Having a breed so heavily af- ligament. By applying the scores
cartilage that partially or completely fected by ED and personally owning of FAA and TPA of sound dogs
separates from surrounding bone. dogs debilitated by the, I found this compared to dogs with disease,
This creates a large loose frag- study presentation and the results they found that TPA and FAA
ment, termed a joint mouse, that to be one of the most exciting of the conformation contributed to
exposes the joint to the underlying conference. predisposition to CCLD.
bone. Treatment options for OCD They also found an
remained unchanged for years, Treatment options for diseases increase in calf muscle
with the common treatments being are important but in some cases, mass in affected
joint debridement (fibrocartilage), being able to predict disease and dogs and noted the
osteochondral transfer, or medical the removal affected animals from increased standing
management. Osteoarthritis is a the breeding pool is the best option, angle of the hock
common side effect of OCD, elbow as proposed in the presentations resulting in
dysplasia and hip dysplasia, and is a given by Dr. Dominique Griffon on increased energy
top 5 complaint by pet owners with predicting cranial cruciate ligament around the hock
80% of dogs having some form of disease in dogs and Dr. Josh Stern's and stifle. She
OA. One of the options for treat- presentation on canine cardiac noted that looking at
ment, Osteochondral Transfer, con- genetics. Dr. Dominique Griffon's standing angle alone
sisted of transplanting an autograph presentation emphasized research does not indicate
aimed at predicting the risk of predisposition
plug from the knee that was canine cruciate ligament disease to CCLD because
then grafted into a prepared (CCLD) using the conformation

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