Page 4 - Extemp Marking Scheme

FAR 222/3 Dosage Form II Extemporaneous Exercise – Marking Scheme 2019 – 2020

CALCULATION

BPC formula 100 mL 30 mL ∆ T/°C E1% NaCl Eqv
Amethocaine 1% 0.3 g* 0.109 0.109/0.576= 0.189x1=
hydrochloride 0.189 0.189% -1M
0.386 0.67 0.0.067% -
Na metabisulphite 0.1% 0.03 g
1M
3 mL (0.02%
PMN 0.002%
stock)
0.256%
qs ad
Distilled water 30 mL NaCl Eqv -
100 mL
1M

Total NaCl eqv = 0.256%
Human eyes can tolerate 0.5 – 2% -1M
It is not isotonic and cannot be well tolerated by our eyes. -1M

NaCl required = 0.9% -0.256% = 0.644%
For 30 mL, 0.19 ~ 0.2 g
METHOD -3M
1. Weigh/measure all ingredients.
2. Add all together in measuring cylinder.
3. Top up with d.water to 30 mL. Mix well. – 0.5M
4. Filter using sintered glass filter grade 3. – 0.5M
5. Check solution using Allen viewer for any particles. – 0.5M
6. Transfer 10 mL of the solution into eye drops bottle using a rinsed measuring cylinder. – 0.5M
7. Close the bottle with closure. – 0.5M
8. Sterilise the preparation by selected method. – 0.5M
9. Label the preparation.
*Dilution needed ( minus 0.5 M for skipping this step)
LABEL – 7M

10 mL
AMETHOCAINE EYE-DROPS B.P.C. 1973 – 0.5M
1 %w/v – 0.5M
Bactericide: Benzalkonium chloride 0.01 %w/v – 0.5M
FIVE (5) drops – 0.5M to be applied to the right eye – 0.5M daily – 0.5M
For external use only – 0.5M
Store in a cool place – 0.5M
Protect from light – 0.5M
Sterile until opened
Use with care to avoid contamination during use
Stored at room temperature
Date of sterilisation: exact date given – 0.5M
Expiry date: 4 weeks after opening (A/C); 2 weeks after sterilization (B), exact date
given– 0.5M
BN: AA1234 (or suitable BN) – 0.5M

Name of patient: ABC – 0.5M Date of dispensing: exact date given – 0.5M

Keep out of Reach of Children
SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG

Product: 5 M

4