Page 6 - Extemp Marking Scheme

FAR 222/3 Dosage Form II Extemporaneous Exercise – Marking Scheme 2019 – 2020

CALCULATION

∆ E1% NaCl Eqv
BPC formula 100 mL 30 mL
T/°C
Homatropine 0.097 0.097/0.576= 0.168x0.57=
hydrobromide 0.57% 0.171 g 0.168 0.096% -1M
Boric acid 1.9% 0.57g 0.288 0.5 0.95% -1M
Sodium sulfite 0.1 % 0.03 g 0.38 0.66 0.066%
15 mL (0.02%
Benzalkonium chloride 0.01%
stock)
qs ad 100 1.11% NaCl
Distilled water 30 mL
mL Eqv -1M

Total NaCl eqv = 1.111%
Human eyes can tolerate 0.5 – 2% -1M
It is almost isotonic and can be well tolerated by our eyes. -1M

METHOD -3M
1. Weigh/measure all ingredients.
2. Add all together in measuring cylinder.
3. Top up with d.water to 30 mL. Mix well. – 0.5M
4. Filter using sintered glass filter grade 3. – 0.5M
5. Check solution using Allen viewer for any particles. – 0.5M
6. Transfer 10 mL of the solution into eye drops bottle using a rinsed measuring cylinder. – 0.5M
7. Close the bottle with closure. – 0.5M
8. Sterilise the preparation by selected method. – 0.5M
9. Label the preparation.
*Dilution needed ( minus 0.5 M for skipping this step)
LABEL – 7M

10 mL
HOMATROPINE EYE-DROPS B.P.C. 1973 – 0.5M
0.57 %w/v – 0.5M
Bactericide: Benzalkonium chloride 0.01 %w/v – 0.5M
FIVE (5) drops – 0.5M to be applied to both eyes – 0.5M at night – 0.5M
For external use only – 0.5M
Store in a cool place – 0.5M
Protect from light – 0.5M
Sterile until opened
Use with care to avoid contamination during use
Stored at room temperature
Date of sterilisation: exact date given – 0.5M
Expiry date: 4 weeks after opening (A/C); 2 weeks after sterilization (B), exact date
given– 0.5M
BN: AA1234 (or suitable BN) – 0.5M

Name of patient: ABC – 0.5M Date of dispensing: exact date given – 0.5M

Keep out of Reach of Children
SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG

Product: 5 M

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