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286 Chapter 6: Genitourinary system

Complications, investigations, treatment Pathophysiology
As for testicular tumours. The Sertoli cells form the testicular tubules and when
stimulated by follicle-stimulating hormone from pu-
berty, they are capable of supporting the maturation of
Sertoli-cell tumour
spermatogonia. Normally they do not secrete sex hor-
Definition mones, but tumour cells may secrete low levels of andro-
This is a non-germ-cell tumour of the testis, derived gens or oestrogens, but these are very rarely high enough
from the Sertoli cells which are part of the seminiferous to cause systemic effects. About 90% are benign.
tubules (sex cords). Also called androblastoma.
Clinical features
As for testicular tumours.
Incidence/prevalence
Less common than germ-cell tumours.
Macroscopy/microscopy
Homogeneous grey-white to yellow masses of variable
Age
size, which are well circumscribed. Normal Sertoli-like
Any. Peak at 40 years.
cellswith tall columnar cytoplasm, often forming cords
like seminiferous tubules. Certain histological features
Sex predict metastasis; for example multiple mitoses and
Male only large cell calcifying cell type.

Aetiology Complications, investigations, treatment
As for all testicular tumours. As for testicular tumours.