Page 77 - Bloedstollig en bloedingsneiging

‘It is the ultimate objective of most biological research to explain phenomena in terms of biochemical reactions. Until a few years ago this was quite beyond the reach of the worker on coagulation; though his subject abounded with hypo- thetical factors and reactions, there was no biochemical knowledge of any of them and their very existence was often in doubt. Now, a series of beautifully integrated investigations has provided a biochemical basis for the transforma- tion of fibrinogen to fibrin, the action of thrombin, and its generation from prothrombin.’
R. Gwyn Macfarlane (1956)1
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