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132 Radiopharmacy | Progress Report
Labeling of molecules for diagnosis – IPEN – CNEN/SP.
(PET and SPECT) and therapy • Training on Preclinical Assays for Radio-
18
• Studies pre-clinicals with F-Choline; pharmaceuticals, Dr Michael Maria Well-
68
• Labelling of PSMA-11 with Ga using ing, Dr. Lorena Pozzo, Dr. Danele Faria, MSc.
synthesis module Paula Feltes, Dr. Marcos Lima. 21 – 25th
• Labelling of PSMA 617 and Rituximab with November. IPEN – CNEN/SP.
177 Lu
• Labelling of Cetuximab with In and Zr REBRATS - NAT – IPEN
111
89
• Trastuxumab with Lu and Cu
111
64
• Development of: a production method for Since late 2016, IPEN is an oficial Nucleus of
MAG3 labeling with 99m Tc Health Techtology Assessment (NAT, from
Portuguese: Núcleo de Avaliação de Tecnolo-
Lyophilized kits – gias) of REBRATS, the Brazilian net for Health
• Development of a production method for Technology Assessment (from Portuguese:
PSMA-11 lyophilized kit labeling with Ga Rede Brasileira de Avaliação de Tecnologias
68
em Saúde), of Ministry of Health.
IAEA Projects
• RLA 6074-006- Curso Regional de Capac- http://rebrats.saude.gov.br/mem-
itación sobre Validación bros-cat/440-instituto-de-pesquisas-en-
• BRA 6027- Improving protocols in nuclear ergeticas-e-nucleares-ipen-cnen-sp
medicine services and in the development
of new radiopharmaceuticals Preclinical Imaging Laboratory
IPEN/USP
The Project IAEA – BRA 6027 - “Improving
protocols in Nuclear Medicine Services and The Faculty of Pharmaceutical Sciences of
in the Development of new Radiopharmaceu- University of São Paulo (FCF – USP) and IPEN
ticals” started on 2016 and is coordinated by had firmed an agreement on 2013 to manage
Lorena Pozzo. It is a collaborative work among the Preclinical Imaging Laboratory at Center
four national institutions: IPEN, CRCN, CDTN of Radiopharmacy, IPEN. This core facility is
and InsCer – PUCRS. During four years, these composed by an experimental bioterium, a
institutions will work to develop and provide room for animal preparation, surgeries and
new Radiopharmaceuticals for PET/CT to the radioactive materials manipulation and a
Brazilian society, like FLT, FCholine FES, PIB dedicated imaging room equipped with a
and FMISO. PET/SPECT/CT scanner for small animals
(Albira-Bruker).
Two events were organized in the scope of
the Project to spread the knowledge about the Since then, the laboratory has developed dif-
Development of new Radiopharmaceuticals ferent researches in a collaborative approach
and pre-clinical tests, including imaging: with FCF – USP and other centers from IPEN
• National Course: Theoretical and practical and USP, as well as other national institutions
techniques on synthesis and quality control for research.
on new PET tracers, Dr. Philip Elsinga, Dr.
Regina Célia Carneiro, Mr. Marcos Vinícius In the period from 2014 to 2016, about 10
Fortes Alba, Dr. Lorena Pozzo. 3 - 7th October projects were developed using this facility,
Instituto de Pesquisas Energéticas e Nucleares
