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136 Radiopharmacy | Progress Report

bottle to the target and the recovery of the Clean Rom
gas after irradiation to the bottle is made
cryogenically with liquid nitrogen, through In the cyclotron facility, there is a clean room,
stainless steel pipes. The control system uses class 10,000, with two double hot cells for
a PC and a PLC with a Siemens SIMATIC S5. synthesis modules and a laminar flow hot
A friendly software permits to control the cell for reception of the final product, as
process in manual mode selecting the desired shown in Figure 9. The cells were acquired
action (valve open/off, pump on/off, and so from Comecer-Italy. This clean room was con-
on) by pointing the appropriate icon on the structed according to regulations in radiation
screen. The fully automated operation mode protection as well as to appropriate rules of
can be selected via keyboard and makes the working under aseptic conditions (GMP).
process flexible.

Cyclone 18

The increase in the demand of F-FDG led to
18
the modification in the law that regulates the
production of radioisotopes in Brazil and also to
the purchasing of a new Cyclotron, dedicated
only to F production and new possibilities for
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positron emission radioisotopes. Cyclone 18,
manufactured by Ion Beam Applications-Bel-
gium, is a fixed-energy cyclotron, accelerating
H- ions up to 18 MeV. The beam intensity is
150 µA. It includes eight independent exit port
allowing eight targets to be simultaneously
mounted on the cyclotron. Figure 8 shows the
Cyclone 18.

Figure 9 – Hot Cells

Inside these hot cells synthesis modules are
installed: two Synthera model, from Ion Beam
Applications (Figure 10a) and three TraceLab
MX model from GE (Figure 10b). These syn-
thesis modules allow the routine produc-
tion of F-FDG, F-NaF and experimental
18
18
production of another radiopharmaceutical
labelled with F.
18

Figure 8 - Cyclone 18

Instituto de Pesquisas Energéticas e Nucleares