Page 13 - PR 2014 2016 06 Radiopharmacy

Radiopharmacy | Progress Report 135

Cyclotron Installation tion using enriched water as target material.

The liquid target system was manufactured
To produce specific radioisotopes, two cyclo- by Ion Beam Applications - Belgium and it
trons are installed in IPEN: basically consists of four main parts: a conical

Cyclone 30

The cyclotron, Cyclone 30 model,
manufactured by Ion Beam Applica-
tions-Belgium, is a compact, fixed-field,
fixed-frequency, that can accelerate
H-ions with energies between 15 and
30 MeV. This energy range and its high
external beam current available (350 A)
is optimum for production of the most
important SPECT and PET cyclotron
radioisotopes used in nuclear medicine:
Figure 7 - Cyclone 30
13
123
15
124
111
11
18 F, C, N, O, Ga, Tl, I, In, I,
201
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64 Cu. Figure 7 shows the Cyclone 30.
collimator of 10 mm diameter, a window
The Cyclone 30 cyclotron has two external holder with two windows cooled by helium
beam lines. One is dedicated to irradiation gas, one for the vacuum side and one for the
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of solid target where Ga and 201 Tl can be target side (Havar of 25 and 50 µm respec-
produced. At the end of the other beam line, tively), a water cooled semi hemispherical
a switching magnet with five exit ports is niobium body and a high pressure valve for
installed. In two of these positions, liquid remote-controlled filling, unloading and
targets are installed and in another exit there purging of the target. In front of the target,
is a gas target, which allows the production there is a four sector collimator, which helps
18
of F and 123 I, respectively. the optimization of the cyclotron parameters.
The production is made with protons of 18
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The target system for production of Ga and MeV and current of 50 µA.
201 Tl was manufactured by Ion Beam Appli-
123
0
cations-Belgium, and it uses a target at 6 For I production, due to the high cost of ac-
with respect to the beam axis, resulting in quisition, IPEN has decided to develop its own
an enlargement of the beam by a factor of system to produce 123 I via 124 Xe irradiation.
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10. The target material ( Zn or 203 Tl) is elec- This system includes a water cooled target
trodeposited on an elliptical area measuring 124 Xe chamber, a double Mo window (50 µm)
10mm x 100mm, giving a typical thickness cooled by helium gas, an alignment system,
of 150 - 170 µm. On the back of the target, which consists of a pair of four sectors colli-
there are fins to increase the water cooling mators and a safety volume cooled with liquid
efficiency. Irradiation with current up to nitrogen and a valve manifold for vacuum and
250 µA is possible. transference of the Xe gas from the storage
124
vessel to the irradiation 124 Xe chamber and
18
124
18
18
At IPEN, F is produced by the O(p,n) F reac- recovery. The Xe transfer from the storage