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Few nuclear dots pattern

(AC-7)

HEp-2 cells, the pattern few nuclear dots merely

shows 1 – 6 dots per cell nucleus – frequently near the

nucleoli. In the late S / G2 phase of the cell cycle, the cells

show relatively many dots (4 – 6). The metaphase

chromatin is usually negative. These nucleolar dots are

denominated Cajal bodies (formerly: coiled bodies).

Primate liver tissue section the dots manifest slightly

augmented in comparison with the HEp-2 cells. The liver may,

however, also show a negative reaction