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Cytoplasmic reticular/AMA
pattern (AC-21)
HEp-2-cells contain the antigens M2, M3, M5 and M9; here
the antibodies produce a coarse speckled fluorescence of
the cytoplasm which does not include the nucleus (previously,
the like wise PBC-relevant nuclear dots also reacting
were wrongly suspected of being stray mitochondria)
Primate liver, shows a speckled fluorescence of the
cytoplasm. The cellnuclei are dark. The reaction of the tissue
is generally weaker than that of HEp-2 cells
