Page 1256 - Veterinary Immunology, 10th Edition
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FIG. 38.2 A diagram showing a possible pathogenesis of systemic
lupus erythematosus.
Pathogenesis
Genetic factors.
Lupus development in humans can be caused by deficiencies of the
complement components C1q or C4. Genes associated with
dendritic cell functions, immune complex processing, T cell
functions and signaling, apoptosis, and B cell functions have all
been implicated in influencing lupus risk. Lupus in humans is
predominantly a disease of women.
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