Page 72 - Heart Transplant Protocol

Heart Function Service: Heart Transplant Protocols

o Acute Demyelinating Encephalomyelitis refractory to PMP
o Rasmussen’s encephalitis
o Progressive seizure disorder which responded to PMP but for medical reasons cannot be
used
 Cardiomyopathy
o Single dose 1000-2000 mg/kg/dose
o

Attachment B

Administration Protocols

1. If patient and vital signs are stable, administration rate may be increased as follows:

IVIG Administration Rate

If using a 10% solution:
Time Initial Infusion/Reduced Rate* Infusion Rate
Initial infusion rate (0.025 g/kg/hour) 0.25 (0.05 g/kg/hour) 0.5
mL/kg/hour mL/kg/hour

After 15-30 minutes at previous (0.05 g/kg/hour) 0.5 mL/kg/hour (0.1 g/kg/hour) 1 mL/kg/hour
rate, may increase to
After 15-30 minutes at previous (0.1 g/kg/hour) 1 mL/kg/hour (0.2 g/kg/hour) 2 mL/kg/hour
rate, may increase to
After 15-30 minutes at previous (0.2 g/kg/hour) 2 mL/kg/hour (0.4 g/kg/hour) 4 mL/kg/hour
rate, may increase to
Maximum Infusion Rate (0.2 g/kg/hour) 2 mL/kg/hour (0.4 g/kg/hour) 4 mL/kg/hour

*Consider reduced infusion rate if patient is at risk for renal insufficiency, thromboembolic events,
volume overload, and/or utilizing 10% solution for initial dose.

2. Lower to previous infusion rate if patient develops:

 Headache
 Fever/chills
 Nausea/vomiting
 Flushing
 Pruritus
 Lightheadedness
 Myalgia or
 Fatigue

If patient symptoms persist, notify prescriber, lower infusion rate further or stop infusions as
ordered until symptoms resolve.

Updated November 9, 2017 72