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Study ID Intervention Comparison Outcome Inclusion Risk of bias Appropriate Number of AMSTAR Author’s
Criteria assessment Statistical articles TOTAL conclusions
methods out of
Jaber et al. Clear aligners Fixed Effectiveness of Human patients of any age Assessed with Not applicable 6 11.5/16 Both clear aligners
2023 orthodontic clear aligners in with complicated and se- RoB 2.0 for RCTs due to clinical and fixed appliances
appliances severe maloc- vere malocclusion requiring and ROBINS-I for heterogeneity effectively treat premolar
clusion cases premolars extraction non-randomized among studies extractions, but fixed ap-
with premolar studies pliances provide superior
extractions. buccolingual inclination
and occlusal contacts
more quickly.
Addi 2023 Clear Aligners Fixed Appli- Effectiveness Permanent dentition, Yes Not specified 5 14.5/16 CA and FA effectively
(CA) ances (FA) in improving malocclusion treatments improve malocclusion;
malocclusion, with CA and FA FA excels in occlusal
occlusal contacts, contacts, transverse
transverse width, width, and buccolin-
and controlling gual inclination, while
posterior bucco- CA offers better teeth
lingual inclination inclination control and
shorter treatment times in
no extraction cases.

References: advantages, disadvantages and effectiveness of 16. Oikonomou, E., Foros, P., Tagkli, A., Rahio-
1. Rossini, G., Parrini, S., Castroflorio, T., & Invisalign aligners. Int. J. Community Med. Pub- tis, C., Eliades, T., & Koletsi, D. (2021). Impact
Deregibus, A. (2015). Efficacy of clear aligners lic Health, 8, 5064. of aligners and fixed appliances on oral health
in controlling orthodontic tooth movement: A 9. Pereira, D., Machado, V., Botelho, J., Proença, during orthodontic treatment: A systematic re-
systematic review. Angle Orthodontist, 85(5), L., Mendes, J. J., & Delgado, A. S. (2020). Com- view and meta-analysis. Oral Health & Preven-
881-889. parison of pain perception between clear aligners tive Dentistry, 19(1), 659-672.
2. Weir, T. (2017). Clear aligners in orthodontic and fixed appliances: a systematic review and 17. Crego-Ruiz, M., & Jorba-García, A. (2023).
treatment. Australian Dental Journal, 62, 58-62. meta-analysis. Applied Sciences, 10(12), 4276. Assessment of the periodontal health status and
3. Rosvall, M. D., Fields, H. W., Ziuchkovski, 10. Morales-Burruezo, I., Gandía-Franco, J. L., gingival recession during orthodontic treatment
J., Rosenstiel, S. F., & Johnston, W. M. (2009). Cobo, J., Vela-Hernandez, A., & Bellot-Arcis, with clear aligners and fixed appliances: A sys-
Attractiveness, acceptability, and value of or- C. (2020). Arch expansion with the Invisalign tematic review and meta-analysis. Medicina
thodontic appliances. American Journal of Or- system: Efficacy and predictability. PLoS One, Oral, Patología Oral y Cirugía Bucal, 28(4),
thodontics and Dentofacial Orthopedics, 135(3), 15(12), e0242979. e330.
276-e1. 11. Ke, Y., Zhu, Y., & Zhu, M. (2019). A com- 18. Jaber, S. T., Hajeer, M. Y., & Sultan, K.
4. Sfondrini, M. F., Gandini, P., Castroflorio, T., parison of treatment effectiveness between clear (2023). Treatment effectiveness of clear aligners
Garino, F., Mergati, L., D’Anca, K., ... & Scrib- aligner and fixed appliance therapies. BMC Oral in correcting complicated and severe malocclu-
ante, A. (2018). Buccolingual inclination control Health, 19(1), 1-10. sion cases compared to fixed orthodontic appli-
of upper central incisors of aligners: a compari- 12. Pithon, M. M., Baião, F. C. S., Sant´ Anna, ances: a systematic review. Cureus, 15(4).
son with conventional and self-ligating brackets. L. I. D. D. A., Paranhos, L. R., & Cople Maia,
BioMed Research International, 2018(1), Article L. (2019). Assessment of the effectiveness of Negin Rezaie is a current
9341821. invisible aligners compared with conventional senior student at NYU
5. Addi, R. A., Benksim, A., & Cherkaoui, M. appliance in aesthetic and functional orthodontic
(2023). The efficacy and efficiency of clear treatment: A systematic review. Journal of inves- College of Dentistry Class
aligners in comparison to traditional fixed appli- tigative and clinical dentistry, 10(4), e12455. of 2025.
ances: a systematic review. J Sci Tech Res, 51, 13. Robertson, L., Kaur, H., Fagundes, N. C. F.,
10-26717. Romanyk, D., Major, P., & Flores Mir, C. (2020).
6. Djeu, G., Shelton, C., & Maganzini, A. (2005). Effectiveness of clear aligner therapy for ortho-
Outcome assessment of Invisalign and tradi- dontic treatment: A systematic review. Orthodon-
tional orthodontic treatment compared with the tics & craniofacial research, 23(2), 133-142. Dr. Analia Veitz-Keenan
American Board of Orthodontics objective grad- 14. Ali Baeshen, H., El-Bialy, T., Alshehri, A., is a Clinical Professor at
ing system. American Journal of Orthodontics Awadh, W., Thomas, J., Dhillon, H., & Patil, S. NYU Dentistry Depart-
and Dentofacial Orthopedics, 128(3), 292-298. (2023). The effect of clear aligners on speech: a ment Oral Maxillofacial
7. Cardoso, P. C., Espinosa, D. G., Mecenas, P., systematic review. European Journal of Ortho- Pathology, Radiology and
Flores-Mir, C., & Normando, D. (2020). Pain dontics, 45(1), 11-19.
level between clear aligners and fixed applianc- 15. Papageorgiou, S. N., Koletsi, D., Iliadi, A., Medicine and Epidemiolo-
es: a systematic review. Progress in Orthodon- Peltomaki, T., & Eliades, T. (2020). Treatment gy and Health Promotion.
tics, 21(1), 1-17. outcome with orthodontic aligners and fixed ap- She has a private practice in Brooklyn,
8. Hosny, M. A. A., Alasmari, F. S., Alsaidi, N. pliances: a systematic review with meta-analy- NY, and is NYSAGD’s 2024-25 president.
M., Alsharif, H. M., Alshareef, S. A., Aldwyyan, ses. European Journal of Orthodontics, 42(3),
N. F., ... & Alhemaidi, G. S. (2021). Indications, 331-343.

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