Page 7 - DIGITAL e-Book RCPH 2026

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1 REGIONAL CONFERENCE onon
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PRECISION HEALTH
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T T h e M a l a y s i a n P a n g e n o m e
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The Malaysian Pangenomee
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The Malaysian Pangenome comprises more than 4,000 genomes, generated through a
combination of short-read, long-read, and telomere-to-telomere (T2T) sequencing
technologies, representing 56 ethnic groups from Malaysia’s rich and diverse population. This is a
landmark scientific achievement. It establishes one of the most important national genomic
resources ever assembled in the country. By capturing the diversity of populations across Malaysia,
the database provides a far more relevant foundation for genomic discovery, variant interpretation,
and future clinical translation. It also helps address a major gap in global genomic resources, where
Southeast Asian populations have historically been underrepresented.
The impact of this resource will be far-reaching. It provides a critical foundation for downstream
applications in disease gene discovery, variant interpretation, population health research,
risk prediction, biomarker development, pharmacogenomics, diagnostics, and the
development of more precise preventive and therapeutic strategies. It can improve the
accuracy of genetic interpretation for Malaysians, support the development of tests and tools better
suited to local populations, and accelerate research into major health priorities such as cancer,
cardiovascular disease, diabetes, rare disorders, and other complex conditions. At the same time, it
strengthens Malaysia’s position as an active contributor to regional and global genomic science.
Looking to the future, the Malaysian Pangenome represents not only a scientific milestone, but a
strategic national platform for the advancement of healthcare, research, and innovation. It will serve
as a foundation for deeper integration of genomics into healthcare, research, and policy. Its future
lies not only in expanding the resource, but also in translating knowledge into better outcomes for
patients and populations — enabling healthcare that is more precise, more effective, more
equitable, and ultimately more impactful for Malaysia and the region.
Lead investigator
Professor Datuk Dr. A Rahman A Jamal
Team members:
Dr. Muhammad Redha Abdullah Zawawi
Dr. Noraidatulakma Abdullah @ Muda
Ts. Muhiddin Ishak
Nazihah Abd Jalal
Nur Alyaa Afifah Md Shahri
Amalia Natasya Saiful Amri
Khoo Jia Shiun