Page 1199 - Basic _ Clinical Pharmacology ( PDFDrive )

Index 1185

Air pollutants, 1006–1009 Alfuzosin, 160 α adrenoreceptor
carbon monoxide, 1006–1007, 1007t Alirocumab, 638, 995 affinities of, 141, 141t
nitrogen oxides, 1007t, 1008 Aliskiren description of, 99, 99t, 138f, 139,
ozone and other oxides, 1007t, heart failure treated with, 220 139t
1008–1009 hypertension treated with, 192t, 193t α-adrenoreceptor antagonists, 156–162,
permissible exposure limit values of, on renin-angiotensin system, 305 170t
1007t on vasoactive peptides, 316t alfuzosin, 160
sources of, 1006 Alitretinoin, dermatologic, 1085 chlorpromazine and haloperidol, 160
sulfur dioxide, 1007, 1007t Alkaloids, cholinomimetic, 109, 110f. clinical pharmacology of, 160–162
Akathisia See also specific types α 2 antagonist applications, 162
antipsychotics as cause of, 522 Alkalosis, metabolic, 260–261 erectile dysfunction, 162
tardive, 506 hypokalemic, 263, 265 hypertension, chronic, 161
Akinesia, end-of-dose, 497 Alkylating agents, 953–957 hypertensive emergencies, 161
ALA photodynamic therapy, 1084 adverse effects of, 954 peripheral vascular disease, 161
Albendazole, for helminths, 938–940, 939t bendamustine, 956 pheochromocytoma, 160–161, 161f
Albiglutide, 762, 769t dacarbazine, 956 urinary obstruction, 161
Albumin concentration, in protein mechanism of action of, 953–954, doxazosin, 159, 159t
binding, 53 954f ergotamine and dihydroergotamine,
Albuterol, 154t. See also Sympathomimetics nitrosoureas, 953f, 954, 956 160
asthma treated with, 351, 359, 362t platinum analogs, 955t, 956–957 hypertension treated with, 184, 191t
structure of, 350f procarbazine, 955t, 956 indoramin, 160
Alcohol(s), 396–408, 406t resistance to, 954 labetalol and carvedilol, 160
antisepsis and disinfection uses of, 898, structures of, 953, 953f mechanism of action in, 156–157
898t Allan-Herndon-Dudley syndrome, 690 pharmacologic effects of
drug interactions with, 402, 1157t Allele, 75t cardiovascular, 157, 158f
ethanol (ethyl alcohol), 396–404. Allele frequency, 75t other, 157, 159
See also Ethanol Allergic rhinitis, 283 phenoxybenzamine, 159, 159t
ethylene glycol, 405–406, 406t Allergic rhinoconjunctivitis, 356, 362t phentolamine, 159, 159t
isopropyl alcohol, 405 Allergy preparations, OTC, 1122t prazosin, 159, 159t
methanol, 405, 405f, 406t Allium sativum, 1135–1136 preparations available, 171t
in OTC agents, 1129t Allopurinol, 71, 83 silodosin, 160
psychological dependence on, 400 angina pectoris treated with, 207, structure and mechanism of action in,
Alcohol abuse, 396–397. See also Ethanol 210t 158f
ionotropic receptors in, 585 drug interactions of, 1157t tamsulosin, 159t, 159–160
pharmacology of, 584–585 gout treated with, 661–662, 662f terazosin, 159, 159t
treatment of, 404, 406t, 407t, 585, 589t hypercalciuria treated with, 788 trazodone, 160
Alcohol dehydrogenase inhibitor, for Allosteric activator, 5, 6f urapidil, 160
methanol poisoning, 405, 406t Allosteric inhibitor, 5, 6f yohimbine, 160
Alcohol dehydrogenase pathway, 397, 397f Allosteric modulators, 21 α-amino-3-hydroxy-5-methylisoxazole-
Alcoholic liver disease, 400 negative, 5, 6f, 24 4-propionic acid, 375
Alcohol-use disorder, 396, 406t–407t. positive, 5, 6f, 24 α-bungarotoxin, 370t
See also Ethanol Allylamines α-glucosidase inhibitors, 761, 768t
Aldactazide, 266t dermatologic topical, 1073 α-linolenic acids, 337
Aldactone, 266t terbinafine, 861t α-methyldopa, 154t. See also
Aldehyde dehydrogenase (ALDH), 67t topical antifungal, 860–861, 861t Sympathomimetics
Aldehydes, 900 Almorexant, 390b α 1 -selective adrenoceptor agonists, 154t
Aldosterone, 703, 714–715 Almotriptan, 291t, 296t α 2 -selective adrenoceptor agonists, 149,
Aldosterone antagonists, 224t, 226t, 265 Aloe, 1099 154t. See also Sympathomimetics,
Aldosteronism, 710–711 Alogliptin, 763, 769t direct-acting
Alemtuzumab, 991 Alosetron α 1 -selective adrenoreceptor antagonists,
Alendronate chemical structure of, 1102f 179t, 184, 193t
bone metastases treated with, 789t irritable bowel syndrome treated with, α 2 -selective adrenoreceptor antagonists,
hypercalcemia treated with, 789t 1102, 1102f 162
osteoporosis treated with, 780b, 786, α 1 -acid glycoprotein concentration, 53 α-synuclein, 493
789t α 1 adrenoceptor Alprazolam, 384, 385t, 390, 393t. See also
Paget’s disease of bone treated with, 789 activation of, 138, 138f Benzodiazepines
Alfentanil, 555t, 567, 572t. See also Opioid cardiovascular system activation by, structure of, 382f
agonists 144–145, 146f, 146t, 147f tremor treated with, 503