Page 1200 - Basic _ Clinical Pharmacology ( PDFDrive )

1186 Index

Alprostadil (PGE 1 ), 323 Amine hypothesis, for depression, 533, Amodiaquine, 919f, 920t, 921
erectile dysfunction treated with, 200b, 534–536, 535f Amoxapine, 540t, 541, 542t, 546t, 549,
335 Amine oxidases, 61t 550t. See also Antidepressant
patent ductus arteriosus treated with, 335 Amino acid neurotransmitters, CNS, 375. agents; Tetracyclic agents
structure of, 333f See also specific types Amoxicillin, rash from, 795, 814
Alteplase, 619 GABA and glycine, 375–378, 376t AMPA, CNS, 375
Alternative health care, 3 glutamate, 375, 376t, 377f AMPA receptors, CNS, 375
Altretamine, 955t Aminocaproic acid (EACA) Amphetamines, 144f, 150. See also specific
Aluminum hydroxide, 1089 coagulation disorders treated with, 611f, types
Alveolar-venous partial pressure difference, 623 abuse of, 577t, 581
444–445, 445f fibrolysis treated with, 611, 611f biogenic amine binding in, 586f,
Alveolar ventilation, 443–444, 444f Aminoglutethimide, 715, 716f 586–587
Alvimopan Aminoglycosides, 826–832, 833t noradrenergic transmitter release by, 95
description of, 571, 572t adverse effects of, 829 poisoning management for, 1041–1042
laxative action of, 1099–1100 amikacin, 827f, 831 structure of, 144f
Alzheimer’s disease, 1062f, 1062–1063, clinical uses of, 829 Amphotericin B, 853–854, 861t
1063t gentamicin, 827f, 830–831 adverse effects of, 855–856
drugs for mechanism of action of, 826–827, 828f antifungal activity and clinical uses of,
antipsychotics, 519. See also mechanisms of resistance of, 827–828 855
Antipsychotic agents neomycin and kanamycin, 831–832 chemistry and pharmacokinetics of,
in elderly, 1062f, 1062–1063, 1063t netilmicin, 827f, 831 853–854, 854t
tacrine, 120 pharmacokinetics and once-daily dosing dermatologic topical, 1073
epidemiology of, 1062 of, 828–829 lipid formulations of, 854b, 854t
with hypertension and age-related physical and chemical properties of, mechanisms of action and resistance to,
macular degeneration, 1058, 1067 826, 827f 854–855, 855f
mechanisms of, 1062, 1062f preparations available, 833t preparations available, 862t
prevention and treatment of, streptomycin, 827f, 829–830 AMP kinase activation, 638
1062–1063, 1063t tobramycin, 827f, 831 Amplification, 35
Amantadine Aminolevulinic acid, for actinic keratoses, Amylin, 747
influenza treated with, 892 1084 Amyl nitrite, 198, 202t. See also Nitrates
parkinsonism treated with, 501 Aminopenicillins, 801. See also Penicillin(s) and nitrites
Ambrisentan, 312, 313b, 317t. See also Aminophylline, 352 Amyloid beta (Ab) peptide, 1062
Endothelin inhibitors Aminosalicylates, 1106–1109, 1107f, 1116t Anabolic steroids, 740. See also Androgens
Amebiasis drugs, 928–931 adverse effects of, 1108–1109 and anabolic steroids
diloxanide furoate, 929t, 930f, 930–931 chemistry and formulations of, abuse of, in sports, 742
emetine and dehydroemetine, 929t, 931 1106–1108, 1107f preparations available, 741t, 745t
iodoquinol, 929t, 930, 930f clinical uses of, 1108 Anacetrapib, 638
metronidazole and tinidazole, 929t, pharmacokinetics and pharmacodynamics Anakinra, 657, 994
929–930, 930f of, 1108 Analgesia
paromomycin sulfate, 929t, 930f, 931 5-Aminosalicylic acid (5-ASA), 1106–1109, in general anesthesia, 446
preparations available, 936t 1107f, 1116t opioids for, 555t, 563. See also Opioid
Amenorrhea, 726, 735 Aminosalicylic acid (PAS), 843t, 848 agonists
American trypanosomiasis drugs Amiodarone, 239t, 240t, 243–244, 251t Analgesics. See also Opioid(s); specific types
benznidazole, 934 Amiodarone-induced thyrotoxicosis, 700 acetaminophen, 56, 64, 65f, 73, 659,
nifurtimox, 933t, 934–935 Amitriptyline 664t
Amides, 61t blocking effects of, 542t disease-modifying antirheumatic drugs,
Amikacin dosing of, 546t 649–659, 664t
description of, 827f, 831, 833t migraine headache prophylaxis using, 291 in elderly, 1061
tuberculosis treated with, 843t, 848 pharmacokinetics of, 540t gout agents, 659–663, 664t
Amiloride Amlodipine ketorolac, 659
diuresis using, 265f, 265–267, 273t angina pectoris treated with, 203t, nonsteroidal anti-inflammatory drugs,
drug interactions of, 1170t–1171t 206. See also Calcium channel 643–649, 645t, 664t
Amine blockers novel targets for, ion channels and, 560b
primary, 9, 60t hypertension treated with, 179t, 187 opioid agonists, 567–569, 572t. See also
quaternary, 9 Ammonium compounds, quaternary, Opioid agonists
reversible protonation of, 9 899–900 OTC, 1123t
secondary, 9, 60t Amnesia, 447b preparations available, 664t
tertiary, 9, 60t Amobarbital, 393t. See also Barbiturates tramadol, 659