Page 1260 - Basic _ Clinical Pharmacology ( PDFDrive )

1246 Index

Toxicology (Cont.): antidepressants, 1041t, 1042 Trazodone, 160, 538, 540t, 542t, 546t,
bioaccumulation and biomagnification antipsychotics, 1042 547, 549t. See also 5-HT
in, 1006b aspirin (Salicylate), 1042–1043 receptor modulators
definition of, 1 beta blockers, 1041t, 1043 Trematodes, 944–945. See also
ecotoxicology, 1005 calcium channel blockers, 1041t, 1043 Anthelmintic drugs
environmental, 1004–1005 carbon monoxide and other toxic gases, Tremor, 492, 503–504
environmental pollutants, 1014–1017 1041t, 1043, 1044t beta-receptor antagonists for, 169
asbestos, 1016–1017 cholinesterase inhibitors, 1041t, definition of, 492
coplanar biphenyls, 1015 1043–1044 essential, 503
endocrine disruptors, 1016 cyanide and hydrogen cyanide, 1041t, intention, 504
perfluorinated compounds (PFCs), 1044, 1044t from lithium, 527
1016 digoxin, 1041t, 1044–1045 rest, 504
polybrominated biphenyl ethers ethanol and sedative-hypnotic drugs, Treprostinil, 324f, 335
(PBDEs), 1015 1041t, 1045 Treprostinil sodium, 333f
polybrominated biphenyls (PBBs), ethylene glycol, 1041t, 1045 Triamcinolone (acetonide), 709t. See also
1015 iron and other metals, 1045 Corticosteroids, synthetic
polychlorinated biphenyls (PCBs), methanol, 1041t, 1045 asthma treated with, 355
1014–1016 opioids, 1041t, 1045 structure of, 706f
polychlorinated dibenzofurans rattlesnake envenomation, 1045 Triamterene
(PCDFs), 1015 theophylline, 1041t, 1045 diuresis using, 262–267, 273t
polychlorinated dibenzo-p-dioxins Toxic uninodular goiter, 699 drug interactions of, 1170t–1171t
(PCDDs, dioxins), 1015 Toxins, 3 Triazolam, 382f, 384, 385t, 389, 393t.
heavy metals, 901, 1020–1029. See also Trademark, 17 See also Benzodiazepines
Heavy metals Train-of-four (TOF) stimulation, 479f, 481 Trichlorfon, 939t, 943
chelators for, 1029–1033, 1033t. Tramadol, 569–570, 572t, 573t, 659 2,4,5-Trichlorophenoxyacetic acid
See also Chelators Trametinib, 975 (2,4,5-T), 1013f, 1013–1014
herbicides, 1013–1014 Trandolapril, 187 Trichogenic and antitrichogenic agents
bipyridyl (paraquat), 1013f, 1014 Tranexamic acid, 623 bimatoprost, 1085
chlorophenoxy (2,4-D), 1013f, Transcranial magnetic stimulation (TMS), eflornithine, 1085
1013–1014 588 finasteride, 1085
glyphosate, 1013f, 1014 Transferases, 63, 64f, 64t. See also specific minoxidil, 1084–1085
metals types Trichomoniasis, 929. See Amebiasis drugs
beryllium, 1017 Transforming growth factor-b (TGF-b), Trichostrongylus orientalis, 945–946
cadmium, 1017 27–28 Trichuriasis. See also Anthelmintic drugs
nanomaterials, 1017–1018 Transient neurologic symptoms (TNS), albendazole for, 938–940, 939t
occupational, 1004 469 mebendazole for, 942
pesticides, 1010–1013 Translational research, 12 Tricyclic antidepressants (TCAs), 549t.
botanical, 1012–1013, 1013f Transmembrane enzymes, ligand-regulated, See also Antidepressant agents
carbamate, 1012, 1012t 27–28, 28f chemistry of, 537, 538f
organochlorine, 1010t, 1010–1011, Transporter genetic variations, 82–83 clinical pharmacology of
1013f Transporters adverse effects in, 547
organophosphorus, 1011t, 1011–1012 MDR1, 8, 8t drug interactions in, 548, 1159t
poisoned patient management in, MRP1, 8t intoxication with, 119
1035–1046. See also Poisoned multidrug resistance-associated protein, pharmacodynamics of, 542t, 542–543
patient management 8, 8t pharmacokinetics of, 540t, 541
solvents, 1009–1010 SERT, 8t poisoning with, 1041t, 1042
aromatic hydrocarbons, 1009–1010 types of, 8t preparations available, 551t
halogenated aliphatic hydrocarbons, VMAT, 8t Trientine hydrochloride, 507
1009 Transport proteins, as drug receptors, 21 Triethylenemelamine, 953f
terminology of, 1005 Tranylcypromine, for depression, 539f, Trifluridine, 865t, 866f, 867
Toxicology screening tests, 1039, 1039t 541, 546t, 549t Trihexyphenidyl, 501t, 508t
Toxic products, drug metabolism to, Trapping, drug, 9, 11f Triiodothyronine (T 3 ), 687, 690–692. See T 3
64–65, 65f Trastuzumab, 35, 971, 993 Trilostane, 716
Toxic syndromes, 1040–1046 Trauma surgery, emergency, 474, 491 Trimetazidine, 207, 210t
acetaminophen, 65f, 1040, 1041t Travelers Trimethadione, 429–430
amphetamines and other stimulants, immunization for, 1182 Trimethaphan, 145
1041–1042 malaria prevention for, 920t Trimethobenzamide, 1106
anticholinergic agents, 1041t, 1042 Travoprost, 337 Trimethoprim, 836–837, 840t