Page 1255 - Basic _ Clinical Pharmacology ( PDFDrive )

Index 1241

Simvastatin, 632–634, 639t Sodium bicarbonate Somatic motor nerves, 90f
Sinecatechins, 1083 antacid actions of, 1089 Somatomedin C, 670
Single nucleotide polymorphism (SNP), aspirin overdose treated with, 1, 19 Somatostatin
69, 75t Sodium-calcium exchanger, 213, 230 description of, 669, 672f, 672–673, 747,
Single-twitch stimulation, 481 Sodium channel, 230 1101
Sinoatrial (SA) node, 127, 228, 229f antiarrhythmic state- and use-dependent variceal hemorrhage treated with,
Sinus rhythm, normal, 236f block of, 236, 238f 1114
Sirolimus, 986–987 in cardiac action potential, 231f, 231–232 Somatostatin analogs, 672f, 672–673
Sirtuins, 1058 resting potential of, 233f Somatotropin 668f, 668–669. See Growth
Sitagliptin, 762, 769t Sodium channel blockers hormone (GH)
Sitaxsentan, 312, 317t. See also Endothelin angina pectoris treated with, 207, 210t, Sonidegib, 1085
inhibitors 211t Sorafenib, 966t, 969
Size, of drugs, 3 arrhythmia treated with, 237–243, 239t, Sorbitol, 1098
Skeletal muscle 240t, 250t Sotalol
calcium channel blocker effects on, 205 class 1A arrhythmia treated with, 239t, 240t,
methylxanthines effect on, 353 disopyramide, 239t, 240t, 240–241, 243, 244–245, 251t
Skeletal muscle relaxants, 474–491. See also 250t properties of, 164t
specific types procainamide, 237–239, 239t, 240t, Sources of information, 18–19
neuromuscular blocking drugs, 250t Spareness, degree of, 22f, 23
474–475 quinidine, 239t, 240, 240t, 250t Spare receptors, 22, 22f
preparations available, 490t class 1B Spasmolytics, 485–487, 489t
spasmolytic drugs, 485–487, 489t lidocaine, 239t, 240t, 241f, 241–242, baclofen, 485–487, 486f, 489t
Skin, 1068. See Dermatologic pharmacology 250t botulinum toxin, 487
SLCO1B1 gene pharmacogenomics, 77t, mexiletine, 239t, 240t, 242, 250t dantrolene, 449, 486f, 487–488, 489t
80t, 82–83 class 1C diazepam, 485, 489t
Sleep aids, OTC, 1127t flecainide, 239t, 240t, 242, 251t gabapentin, 487
Sleep-enabling drugs, 390b moricizine, 243, 251t glycine, 487
Sleeping sickness, 931. See African propafenone, 239t, 240t, 242–243, idrocilamide, 487
trypanosomiasis 251t local muscle spasm treated with, 488
Sleep-wake cycle, melatonin receptors in, preparations available, 251t mechanisms of action of, 485, 486f
384b Sodium etidronate, for Paget’s disease of preparations available, 490t
Slow acetylator, 69 bone, 789 progabide, 487
SLV306, 316t Sodium ferric gluconate complex, for iron- riluzole, 487
Small interfering RNAs (SiRNAs), deficiency anemia, 595, 605t spasticity and, 485, 486f
therapeutic, 2 Sodium-glucose cotransporter 2 (SGLT2) tizanidine, 486f, 487
Smoking, 120, 583. See Nicotine description of, 256, 256f Spasticity, 485, 486f
Smoking cessation aids, OTC, 1127t inhibitors of, 261–262, 272t, 274t, Special carrier molecules, 8, 8f
Smooth muscle 763–764, 769t Spectazole, 1072
alcohol effects on, 398 Sodium hypochlorite, 899 Spectinomycin, 832–833, 833t
calcium channel blocker effects on, Sodium nitroprusside, 342 Spina bifida, 434
204 Sodium phosphate, 1098 Spinosad, 1075
contraction of, calcium channel blocking Sodium pump, 214f, 217, 230 Spiramycin, 928
drugs on, 196f, 197 Sodium removal, for chronic heart failure, Spironolactone, 191t, 224t, 717. See
methylxanthines effect on, 353 221–222 also Aldosterone antagonists;
prostaglandins effect on, 327 Sodium stibogluconate, 930f, 932t, 933 Diuretics
thromboxanes effect on, 327 Sodium sulfacetamide, 1071–1072 antiandrogen actions of, 745
SN-38, 964 Sodium thiosulfate, 199 diuresis uses of, 265f, 265–267, 273t
Snake bite treatment Sodium valproate, 426f, 426–427, 436t drug interactions of, 1170t–1171t
coral snake, 991, 1181t Sofosbuvir, 889 heart failure treated with, 220
rattlesnake, 991, 1045, 1181t Solanezumab, 1063 SR142948A, 314
SNAP-25, 95 Solid organ transplantation, 996 SRX251, 308, 317t. See also Vasopressin
Sniffing, 585 Solifenacin, 131, 135t. See also Muscarinic receptor antagonists
Social anxiety disorder, 544 receptor blockers SSR240612, 308
+
Sodium (Na ) Solvents, 1009–1010 St. Anthony’s fire, 292
dietary restriction of, 189 aromatic hydrocarbons, 1009–1010 St. John’s wort (Hypericum perforatum), 70,
in membrane electrical activity, halogenated aliphatic hydrocarbons, 1009 71t, 1139–1140
229–230, 230f Somatic division, of autonomic nervous Stable effort angina, 194, 211
in OTC agents, 1129t system, 89 Staccato, 435