Page 225 - Atlas of Histology with Functional Correlations

maturation and segmentation of the nucleus into distinct lobes, the neutrophils

pass through a band cell (10) stage, in which the nucleus assumes a nearly
uniform curved rod or band shape.

Mature neutrophils (13) with segmented nuclei are also present in the bone
marrow smear, as well as a mature eosinophil (7) with specific pink granules
filling its cytoplasm.

A section of a giant cell megakaryocyte (17) is visible. These cells measure

approximately 50 to 100 μm in diameter and have a large, slightly acidophilic
cytoplasm filled with fine azurophilic granules. Cytoplasmic fragments are shed
from megakaryocytes as platelets (18).

FIGURE 6.13 ■ Bone marrow smear: development of different blood cell types.
Stain: Giemsa stain. High magnification.

Figure 6.14 | Bone Marrow Smear: Selected

Precursors of Different Blood Cells

This illustration shows at a higher magnification the selected precursor cells of
different blood cells that develop and mature in the red bone marrow.

A common stem cell gives rise to different hematopoietic cell lines, from
which arise erythrocytes, granulocytes, lymphocytes, and megakaryocytes.

Because of its ability to differentiate into all blood cells, this cell is called the
pluripotential hematopoietic stem cell.

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