Page 60 - Book of Invited & Keynotes Talks

th
8 Biannual Conference on Chemistry - CHEM 08

Difunctional Compounds as Precursors for Novel bis-
Heterocycles
Ahmed H. M. Elwahy*
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt

ABSTRACT
Heterocycles are an important class of compounds that exist in nature as a part of
vitamins, hormones, alkaloids and many natural products. They are also present in a wide
variety of drugs, as well as biologically active compounds. Most of the heterocycles also
find applications in medicine, agriculture, industry and in combinatorial and
supramolecular chemistry.[1–3] Especially, compounds including bis-heterocyclic
moieties were encountered in many bioactive natural products. Recent reports showed
that among libraries of derivatized heterocycles, the most active library compounds have
a bis-heterocyclic structure. In this respect, bis-heterocycles in which two bioactive
heterocycles are tethered via a flexible linker were reported to be anticancer,
antimicrobial agents, antialzheimer and antiprion activity.[4-12] The development of
efficient and selective synthetic routes as well as novel structures of bis-heterocyclic
systems constitutes an important issue in organic synthesis.
References

1) Eicher, T., Hauptmann, S., Speicher, A., The chemistry of heterocycles : structure,
reactions, synthesis and applications, Wiley-VCH, 2012.
2) Katritzky, A.R., Rees, C.W., Comprehensive heterocyclic chemistry : the structure,
reactions, synthesis, and uses of heterocyclic compounds, Pergamon Press, 1984.
3) Katritzky, A., Ramsden, C., Joule, J., Zhdankin, V., Handbook of heterocyclic chemistry,
Elsevier, 2010.
4) Antonini, I.; Polucci, P.; Magnano, A.; Sparapani, S.; Martelli, S. J. Med. Chem. 2004, 47,
5244-5250.
5) AM Abdelmoniem, SAS Ghozlan, H Butenschön, DM Abdelmoniem, Ahmed H. M.
Elwahy, Ismail A. Abdelhamid , Arkivok, 2019, v, 163-177.
6) ME Salem, AF Darweesh, MR Shaaban, AHM Elwahy, Arkivok, 2019 v, 73-88.
7) ME Salem, M Hosny, AF Darweesh, AHM Elwahy, Synthetic Communications, 2019, 49
(18), 2319-2329.
8) HM Diab, WMI Hassan, IA Abdelhamid, AHM Elwahy, Journal of Molecular Structure,
2019, 1197, 244-261.
9) MF Mohamed, NS Ibrahim, AHM Elwahy, IA Abdelhamid, Anti-Cancer Agents in
Medicinal Chemistry 2018, 18, 2156-2168.
10) NS Ibrahim, MF Mohamed, AHM Elwahy, IA Abdelhamid, Letters in Drug Design &
Discovery, 2018, 15 (10), 1036-1045.
11) MF Mohamed, AM Abdelmoniem, AHM Elwahy, IA Abdelhamid, Current cancer drug
targets, 2018, 18 (4), 372-381.
12) SK Salama, MF Mohamed, AF Darweesh, AHM Elwahy, IA Abdelhamid, Bioorganic
Chemistry, 2017, 71, 19-29.

BOOK OF INVITED SPEAKERS & KEYNOTES CHEM 08 (2020) Page 60