Page 62 - Book of Invited & Keynotes Talks

th
8 Biannual Conference on Chemistry - CHEM 08

Multicomponent Synthesis of Novel Heterocycles via Michael
Addition, Hantzsch, Biginelli, Baylis-Hillman and π4+ π2
Cycloaddition Reactions

Ismail Abdelshafy Abdelhamid
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt.

ABSTRACT
The reported approaches for the synthesis of heterocycles include carbon-heteroatom
bond formation. The synthesis through carbon-carbon bond formation is little bit more
difficult, multistep and usually occurs using the transition metals as catalysts for C–H
bond functionalization. In our work we managed to achieve this target using the simple
reactions that include Michael addition 1–3 , Hantzsch 4–7 , Biginelli 8–10 Baylis-Hillman 11,12
4
2
and π +π Cycloaddition 13,14 reactions.
References :
(1) Ghozlan, S. A. S.; Ramadan, M. A.; Abdelmoniem, A. M.; Abdelhamid, I. A. Arkivoc
2019, 30.
(2) Diab, H. M.; Abdelhamid, I. A.; Elwahy, A. H. M. Synlett 2018, 1627.
(3) Abdelhamid, I. A.; Darwish, E. S.; Nasra, M. A.; Abdel-Gallil, F. M.; Fleita, D. H. Synthesis
2010, 1107.
(4) Abdelhamid, I. A.; Darweesh, A. F.; Elwahy, A. H. M. Tetrahedron Lett. 2015, 56, 7085.
(5) Abdelmoniem, A. M.; Elwahy, A. H. M.; Abdelhamid, I. A. Arkivoc 2016, iii, 304.
(6) Kassab, R. M.; Elwahy, A. H. M.; Abdelhamid, I. A. Monatshefte für Chemie - Chem.
Mon. 2016, 147, 1227.
(7) Mohamed, M. F.; Darweesh, A. F.; Elwahy, A. H. M.; Abdelhamid, I. A. RSC Adv. 2016,
6, 40900.
(8) Darwish, E. S.; Abdelhamid, I. A.; Nasra, M. A.; Abdel-Gallil, F. M.; Fleita, D. H. Helv.
Chim. Acta 2010, 93, 1204.
(9) Ghozlan, S. A. S.; Abdelhamid, I. A.; Gaber, H.; Elnagdi, M. H. J. Chem. Res. 2004, 2004,
789.
(10) M.E. Hassaneen, H.; A. Abdelhamid, I. Curr. Org. Synth. 2013, 10, 974.
(11) Abdelhamid, I. A.; Darwish, E. S.; Nasra, M. A.; Abdel-gallil, F. M.; Fleita, D. H. Arkivoc
2008, 2008, 117.
(12) Al-Awadi, N. A.; Ibrahim, M. R.; Abdelhamid, I. A.; Elnagdi, M. H. Tetrahedron 2008, 64,
8202.
(13) Abdelhamid, I. A.; Habib, O. M. A.; Butenschön, H. European J. Org. Chem. 2011, 2011,
4877.
(14) Al-Mousawi, S. M.; Abdelhamid, I. A.; Moustafa, S. Arkivoc 2007, 2007, 213.

BOOK OF INVITED SPEAKERS & KEYNOTES CHEM 08 (2020) Page 62