Page 37 - Org 3 theoritical book 2024-25
P. 37

Clinical Pharmacy PharmD - 2024/2025                  Level 2                Pharmaceutical Organic Chemistry-3 (PC 305)

                   Reactions of pyrrole:

              1. Electrophilic substitution reactions:































            The pyrroyl potassium as an example of N-metallated pyrroles (Li, Na, Mg ...)

            has a great synthetic value. It reacts with CO 2 and with chloroform as do phenols

            in the Kolbe and Reimer-Tiemann reactions to form pyrrole carboxylic acids

            and  pyrrole-2-carboxaldehyde,  respectively  (in  the  latter  case  some  3-

            chloropyridine is also formed by ring expansion).
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