Page 40 - Org 3 theoritical book 2024-25

Clinical Pharmacy PharmD - 2024/2025 Level 2 Pharmaceutical Organic Chemistry-3 (PC 305)
B. Ring substitution

• Furan undergoes all the electrophilic substitution reactions mainly at 2- and 5-

positions.

• Because of its resinification under effect of acids or acidic reagents, special

reaction conditions are used as follows:

C. Reactions of furan: 1. Electrophilic substitution:

2.Formylation of furan , Gatterman reaction:

ZnCl
+ HCN + HCl 2 CHO
O O

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