Page 41 - Pharmaceutical Organic Chemmistry-3 (Theoritical book) 24-25
P. 41

Clinical Pharmacy PharmD - 2024/2025                  Level 2                Pharmaceutical Organic Chemistry-3 (PC 305)
            B. Ring substitution


            •  Furan  undergoes  all  the  electrophilic  substitution  reactions  mainly  at  2-  and  5-

               positions.

            •  Because  of  its  resinification  under  effect  of  acids  or  acidic  reagents,  special

               reaction conditions are  used as follows:


            C. Reactions of furan: 1. Electrophilic substitution:


































            2.Formylation of furan , Gatterman reaction:


                                                               ZnCl
                                             +  HCN  +  HCl         2           CHO
                                       O                                   O

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