Page 171 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)
vascular smooth Skin Coronary & Pulmonary & Cerebral
muscle vessels
➢ Has the greatest innervations  help in temp. regulation?
Have little sympathetic
✓ ↑ Ambient temperature  cutaneous VD  loss of excess body
innervations.
heat.
How to be controlled?????
✓ Cold condition ➔ cutaneous VD → ……………..

B) Other vasoactive  Examples  Histamine & Bradykinin ➔ released in case of inflammation (in response tissue energy &
hormones trauma.)
a) arteriolar dilation (VD).
b) Increase filtration out of the capillaries [pressure of capillaries > interstitial fluid]➔ fluid get out ➔
local edema.

Relationship between Arterial Blood Pressure (ABP) & COP & TPR

Effect on Constriction of blood vessel

↑ V.C ➔↑ TPR ➔ ↑ BP

V.C in arterioles:

• ↑ BP in arteries

• ↓ BP in Capillaries
➢ HR or SV or COP or TPR   ABP • SBP Is the highest at
➢ VC & VD of arterioles affect  TPR & ABP & Blood flow Aorta
through capillaries.

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