Page 173 - Physiology and Pathophysiology MNU 2024-2025 نظرى
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Clinical pharmacy 2024/2025             Level 2 Pharm D                       Physiology and Pathophysiology (MD303)
 Factors that influence mean arterial pressure  عاتب ميدقلا ملاكلا ركتفن COP , TRP


 Parameter            Determined by

 i.   Blood volume [in kidney failure]   Fluid intake    & Fluid loss
 ii.   Effectiveness of the heart as a pump (cardiac   Heart rate        &   Stroke volume
 output )
 iii.   Resistance of the system to blood flow    Diameter of the arterioles
 iv.   Relative distribution of blood between arterial   diameter of the veins

 and venous blood vessels    Veins dilated ➔ blood static ➔ low pressure.
  veins constriction ➔ increase Venous return ➔ increase BP










 NB

 ↑arterial blood pressure due to   Total peripheral resistance   VC, VD of arterioles affect :

 ↑Of heart rate , stroke volume ,  cardiac output or     sum of all the vascular resistance   •  TPR
 total peripheral resistance (TPR)   within the systemic circulation    •  Arterial pressure

   determined by the arteriolar   •  Blood flow through capillaries
 resistance







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