Page 204 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)

4- Stomach

Functions of the stomach:

a. Stores food.
b. Mix food with gastric secretion.
c. Initiates digestion of proteins.

d. Kills bacteria  due to HCl.
e. Moves food (chyme) into intestine.
f. Minor role in digestion & absorption of nutrients.

Gastric secretions

• The human stomach secretes 1 - 2 L of gastric juice per day.

• The gastric mucosa, which produces these secretions, is divided into 2 functional
regions.
•

1. Oxyntic gland area

• Located in the proximal 80% of the stomach.
• These glands consist of three types of cells:

Stomach cells Secretions

mucous
Mucous neck A thick layer of mucus adheres to the wall of the stomach 

cells
gastric mucosal barrier  protect the gastric mucosa from injury
by the corrosive actions of HCl & pepsin.

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