Page 207 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)

2- Gall bladder:

Stores Bile

 Secreted by liver  diverted to gallbladder between meals.
 Stored & concentrated in gallbladder.
 Consists of
• Bile salts -Cholesterol-Lecithin-Bilirubin
 After meal, bile enters duodenum, how?
Fat  enter duodenum  release of Cholecystokinin hormone  stimulate

gallbladder to contract  secretes bile salt to duodenum.

3- Pancreas

Mixture of exocrine & endocrine tissue

♠ Endocrine: Islets of Langerhans  Secrete insulin & glucagon
♠ Exocrine: Secretes pancreatic juice consisting of:

secreted by acinar cells that form the acini.
1- Proteolytic enzymes  digest protein

a. Trypsinogen - converted to active form trypsin.
Pancreatic b. Chymotrypsinogen – converted to active form chymotrypsin.
enzymes:
c. Procarboxypeptidase – converted to active form
carboxypeptidase.

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