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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

4. Selective 2 agonists:

Salbutamol, terbutaline, fenoterol. and long acting (Salmeterol and formoterol).

uses Side effects advantages

effective tremors, nervousness, 1. long duration of action
bronchodilators tachycardia and 2. much less toxic effect on the heart.
weakness 3. most of them are effective after oral

administration and inhalation

Self-Learning: Search for Once daily newly approved drugs?

5. Selective B 1 agonist:

Dobutamine chemically related to dopamine
Selectivity Effects and use

activity results from stimulation of ✓ greater inotropic than chronotropic effects
β1 adrenoceptors of the heart. ✓ dose-related increase in cardiac output in-patients

It has minor α and β2 effects. with congestive heart failure.

6. Selective B 3 agonist

Mirabegron & Amibegron & rabegron
Used in urine urgency or uncontrollable contraction of bladder ➔ as it causes relaxation

of Urinary Bladder ➔ collect urine for a long period
S/E: Tachycardia, stomach pain, itching, dizziness

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