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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

β-adrenoceptor blockers

st
 1 generation β-blockers (non-selective β blocker) ➔ propranolol.
nd
 2 generation β- blockers (selective β1 blocker) ➔ atenolol & metoprolol. & ...
(Self-learning)

rd
 3 generation β- blockers: selective β1 + vasodilatory properties ➔ carvedilol,
Labetalol
 NB: selective β2 blocker: butaxamine  used experimentally. (Bronchoconstriction)

Pharmacological Action

 -ve inotropic & -ve chronotropic effects ➔  C.O.P

CVS ➔  myocardial oxygen consumption.
 -ve dromotropic effect (slow A-V conduction)
 -ve bathochromic effect So,  BP in hypertensive patients

 β- Blockers ➔  IOP in open angle glaucoma ( aqueous humor
Eye
formation &  aqueous outflow: e.g. Timolol

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