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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

Clinical uses

➢  Bronchial & salivary secretions ➔ decrease pneumonia &
Preanesthetic reflex bronchoconstriction
medication:
➢ Prevents reflex bradycardia that occurs with some anesthesia.

In ➢ Mydriasis & paralysis of (circular muscle) accommodation is
ophthalmology: useful in ➔ ttt of various inflammatory conditions of the eye
e.g. iritis & ophthalmoscopic examination of retina & optic disc.

➢ Relieves hyperchlorhydria ( gastric secretions) &  gastric
GI disorder:
motility ➔ Motility is more affected than secretion

➢ Atropine control hyperhidrosis, a condition of increasing
Secretions:
sweating & excessive secretions.

➢ Hyoscine is useful for its central action in preventing motion
Motion sickness:
sickness; however, dry mouth & drowsiness are side effects.

➢ Antagonize central effects of organophosphorus compounds.
Central effects: ➢ In large doses, in the therapy of schizophrenia.
➢ Treatment of Parkinsonism.

 II- scopolamine (Hyoscine)

➢ Produce peripheral effects similar to those of atropine.
Vs. atropine
➢ greater action on the CNS [longer duration]
➢ most effective anti-motion sickness drugs available [patch]
➢ unusual effect of clocking short-term memory (pre-surgery)
Action ➢ Sedation (In contrast to atropine), but at higher doses it can produce

excitement instead
➢ euphoria ➔ susceptible to abuse

1. limited to prevention motion sickness
 much more effective prophylactically than for treating motion
sickness once it occurs.
Uses
2. blocking short-term memory

The amnesic action of scopolamine ➔ makes it an important adjunct drug
in anesthetic procedures (DOC)
Kinetics &

S/E These aspects are similar to those of atropine (more half-life)

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