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Clinical pharmacy 2024/2025                            Level 3 Pharm D                             Pharmacology 1 (PO 502)

                                           Synthetic atropine-like drugs

             Examples                           Character                                Oxybutynin
         1-  oxybutynin                 Treat over activation urinary           ✓  better tolerated (S/E)
         2-  darifenacin        Uses    bladder disease.                            because it causes less

         3-  solifenacin                dry mouth, constipation, and                dry mouth than do oral
         4-  fesoterodine               blurred vision, which limit                 formulations and is more
         5-  tolterodine.       S/E     tolerability of these agents if             widely accepted with

         6-  trosoium                   used continually.                           greater patient
             chloride                               NB                              acceptance.
                                     The overall efficacies of these            ✓  transdermal system

                                    antimuscarinic drugs are similar.               (topical patches)
























































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