Page 59 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

1. Postoperative muscle pain.
2. Malignant hyperthermia.

➢ Hypotension, 3. Bradycardia, salivation &  IOP.
bronchospasm & 4. Myoglobinemia. (myoglobin is hemoglobin
allergy. in muscle ➔ release due to muscle damage)
➢ D-tubocurarine is 5. Succinylcholine apnea due to:
ADR &
contraindicated in ➢ Patients with abnormal pseudo
toxicity:
allergic patients, renal cholinesterase.
disease & bronchial ➢ After repeated or prolonged

asthma. Succinylcholine administration.
➢ Acquired deficiency of pseudo
cholinesterase due to liver disease,

malnutrition.
1. Artificial respiration.

Treatment 2. Neostigmine with 1. Controlled ventilation.
2. Fresh plasma or blood to restore the
atropine ➔ to prevent level of pseudo cholinesterase enzyme.
bradycardia.

Uses of neuromuscular blockers:

1. Induce muscular relaxation during general anesthesia.
2. For endotracheal intubations.
3. Prevention of coughing & spasm during surgery.

4. Facilitate mechanical ventilation.
5. Control convulsions during electroconvulsive therapy.

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