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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

4- Angiotensin Receptor Blockers (ARBs)

ex: Losartan Prototype, 6 additional

MOA block Angiotensin receptor 1 (AT 1) ➔ alternative for ACEI
1) Arteriolar & venous dilation. ➔ peripheral resistance
Effect 2)  Na and water retention (diuretic effect).
+
+
(similar to AECIs) Block Aldosterone secretion ➔  B.P & Na , water retention ➔
↓ remodeling
Advantages over 1) don't increase bradykinin ➔ No dry cough and ↓ Angioedema

ACE-I 2) ↓nephrotoxicity of diabetes ➔attractive therapy in
hypertensive diabetic patients
S/E st
) as ACEIs) Low Angioedema, 1 dose of syncope, Fetotoxicity

 Examples

➢ Azilsartan

➢ Candesartan

➢ Irbesartan
➢ Losartan

➢ Olmesartan

➢ Telmisartan

➢ Valsartan

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