Page 82 - pharma 1 theoretical updated MNU_Neat

Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

5- Renin antagonist

ex: Aliskiren & Remikiren

Directly inhibit renin in renin angiotensin aldosterone system than
MOA ARBs & ACEIs

Effectiveness ↓ B.P about as effective as ACEIs & thiazide diuretic

Combine with other antihypertensive agents as diuretics, ACEIs,
Combination
+
ARBs, K channel blockers.
Metabolize by CYP450 & so subjected to drug interaction (enzyme
kinetics
inducers or inhibitors).

6- Calcium channel blockers

➢ recommended when first-line agents are contraindicated or
ineffective. (Asthma, Dry cough, angioedema, diabetes, renal
Availability dysfunction)

➢ effective in treating hypertension in patients with angina or diabetes
(β-blockers ➔ hyperglycemia)
➢ High doses of short-acting Calcium channel blockers should be

Caution avoided ➔ because of increased risk of myocardial infarction
due to excessive vasodilation and marked reflex cardiac stimulation
➢ Divided into three chemical classes, each with different

Classification pharmacokinetic properties and clinical indications. (act on heart,
blood vessels).

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