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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

3. Dihydropyridines

First-generation Second-generation
Nifedipine [nicardipine, felodipine, isradipine,]
Classification
rapidly expanding class differ in pharmacokinetics, approved uses, and
drug interactions.

greater affinity for vascular calcium channels than for calcium channels in
selectivity
the heart. ➔Attractive in treating hypertension.

Little interaction with other cardiovascular drugs, such as digoxin or
Advantages warfarin (anticoagulant) ➔ which are often used concomitantly with
calcium-channel blockers.

rd
 Amlodipine is 3 generation Dihydropyridines
th
 Lercanidipine, a newer CCB (4 generation), is reported to exhibit fewer side effects,
such as peripheral edema, and is believed to have beneficial effects on myocardial

ischemia and congestive heart failure.

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