Page 41 - phytochemistry general program

( - ) Quinine (+) quinidine when warmed with KOH in amyl
alcohol.

Totaquine:

is a combination of total alkaloids of cinchona and is employed for the same
purpose of quinine.

Identification of cinchona alkaloids

1- Thalleioquin test

Few drops of bromine water + solution of quinine salt, + ammonia solution

emerald green colour is produced.

This reaction is sensitive to quinine (0.005% solution give +ve reaction).

It is also given by quinidine but not with cinchonidine or cinchonine. .1

2- Fluoresence test

Quinine and quinidine show blue fluorescence with dil. oxygentated acids .2
(e.g. sulphuric or phosphoric )

Estimation of Cinchona alkaloids

spectrophotometric method .1
Gravimetric method .1

Action and uses of Cinchona alkaloids

Quinine has antimalarial activity in a dose of 300-600 mg of quinine sulfate .1
or other salt for 14 days.

Quinine is used as bitter tonic (tonic water). .2

Quinidine is used for treatment of auricular fibrillation in a dose of 200 mg of .3
quinidine sulfate daily

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