Page 139 - Phytochemistry 2 (06-PG 605)
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2- Quercetin, naringenin (…), flavopiridol….
Inhibit cyclins and cdk
Quercetin is an ATPase-mimic due to its planar bicyclic
chromone ring system. It is an isostere ofadenine.
It blocks cell cycle at G0\G1 interphase.It
has moderate anticancer activity
3- Monoclonal antibodies
Stimulate patient immune system to attack and
destroy cancer cells. e. g. rituximab, used for CD20 in
lymphoma B-cells
Recently antibody-drug conjugate
