Page 148 - Phytochemistry 2 (06-PG 605)

Cytarabine, also inhibits both DNA and
RNApolymerases
and nucleotide reductase enzymes needed for

DNAsynthesis.

Cytarabine is the first of a series of anticancer drugs
thataltered the sugar component of nucleotides. Other
cancer drugs modify the base

Adminstration
i.v., under the skin, into cerebrospinal fluid
Uses:
Treat ALL, non hodgkin’s lymphoma, myeloid leukemia