Page 158 - Phytochemistry 2 (06-PG 605)
P. 158
ii- Anticancer drugs stabilize microtubulesagainst
depolymerization.
distinct bundles of microtubules could be seen in the cells
having tetraploid DNA content (4N), resultin cell death .
Examples are: taxanes
Further research has indicated that paclitaxel induces
apoptosis (cell death) in cancer cells bybinding to an
apoptosis stopping protein (Bcl2)