Page 158 - Phytochemistry 2 (06-PG 605)
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ii- Anticancer drugs stabilize microtubulesagainst
depolymerization.
distinct bundles of microtubules could be seen in the cells
having tetraploid DNA content (4N), resultin cell death .
Examples are: taxanes
Further research has indicated that paclitaxel induces
apoptosis (cell death) in cancer cells bybinding to an
apoptosis stopping protein (Bcl2)
