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Topical Semi Solid Dosage Forms

Intended Learning Outcomes
At the end of the lecture:

▪ Understand the concept of the semisolid dosage forms, types, advantages and disadvantages

▪ Differentiate between different types of semi solid dosage form preparations

▪ Describe the characteristics of an ideal preparation in each form and the factors governing
the selection of the essential ingredients, preparation, formulation and quality control

Recommended References
▪ Ansel's pharmaceutical dosage forms and drug delivery systems, Eleventh Ed., Lippincott
Williams & Wilkins, 2017

▪ Remington: The Science and Practice of Pharmacy, 21st edition, University of the Sciences
in Philadelphia (Editor), Lippincott Williams & Wilkins, 2005

▪ Pharmaceutics: The Science of Dosage Form Design. By Michael Aulton.

▪ Pharmaceutical Compounding and Dispensing. John F Marriott, Keith A Wilson,
Christopher A Langley and Dawn Belcher. Chapter 9 & 10. Second Ed., Pharmaceutical
Press 2010.

▪ British Pharmacopoeia. 2018. Semisolid preparations for cutaneous applications. The
Stationery Office on behalf of the Medicines and Healthcare products Regulatory Agency
(MHRA).

What are semi solid dosage forms?
▪ Semisolid dosage forms are preparations intended to be applied to the skin, or to the surface
of certain mucous membranes (eye, ear, oral cavity, nose, vagina or rectum) for local or
systemic effects

▪ Most these preparations are either:

❖ Medicated: (contain therapeutic agent)

❖ Non-medicated: Used for their physical effects as protectants or emollients (softens skin
and makes it elastic)

Site of application

They are applied either to the skin or the mucus membrane (eye, nasal, or in body cavities;
vaginal or rectal)

Therapeutic effect of semi-solid preparations:

Eiter local (topical) or systemic (transdermal) effect

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