Page 66 - Pharmaceutics-II (02-06-01 203)

Evaluation of Transdermal patches

1. Thickness of the Patch
▪ As the uniform thickness of the patch is desired, its thickness is
measured by digital micrometer at various points (three different
places), and the average thickness is calculated to verify whether
the thickness of the fabricated patch is within the intended limit.
▪ The thickness is a rough estimate of drug content uniformity all
over the patch surface and matrix.

2. Weight uniformity
▪ Weight uniformity should be verified among the patches of same batch and from batch to
batch. Before weighing, the patches were dried to a constant weight at 60°C for a fixed
period.
▪ 10 patches are selected randomly and weighed accurately. The average weight was
calculated. The individual weight should not deviate significantly from the average weight

3. Folding Endurance
▪ This test was carried out to check the efficiency of the plasticizer and the strength of the
patch prepared using different polymers.
▪ The folding endurance is the measure of flexibility of the dried films
▪ It is determined as the number of times that the patch of the specified area can be folded at
the same location without breaking

65