Page 61 - phytochemistry II -pharmD general
P. 61
5. Atropine methobromide
It is used as antispasmodic.
6. Atropine methonitrate
It is used as antispasmodic.
7. Homatropine methyl bromide
It is used orally similar to atropine, i:e reduce over secretion & relief
gastroinestinal spasm.
C. Hyoscine (Scopolamine)
Me
N OH
O
H
H
O
O
l (-)- Hyoscine (Scopolamine)
Properties
It is the major alkaloid in Duboisia and scopolia species and Datura metel. It
is laevorotatory, it occurs as syrupy liquid. Enzymatic hydrolysis with lipase yields
L tropic acid and scopine.
Scopolamine HBr is the most commonly used salt for medicinal purposes.
Uses
The action of scopolamine differs from that of hyoscyamine and atropine in that
there is no central nervous system stimulation, BUT rather a narcotic or sedative
effect predominates.
✓ Hyoscine HBr is used as Sedative
✓ Hyoscine base transdermally as antiemetic after surgery
✓ Its benzoate ester used in treating hyperhidrosis (excessive sweating).
60
